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一个协同的双原子站点纳米酶增加免疫细胞死亡,以提供有效的免疫疗法

Shipeng Ning¹, Zeyuan Zhang^2,3,4, Yujing Ren⁵

¹Department of Breast Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|December 24, 2024

概括

一种新型的双原子纳米酶通过产生活性氧物种,有效诱导免疫细胞死亡 (ICD). 这种方法在与抗PD-L1阻断相结合时增强了癌症免疫疗法,为瘤治疗提供了一个有前途的策略.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
免疫学免疫学免疫学

背景情况:

诱导免疫细胞死亡 (ICD) 对于有效的抗瘤免疫反应至关重要.
开发高效的ICD诱导剂是癌症免疫治疗研究的一个活跃领域.

研究的目的:

开发一个级联双原子纳米酶 (FeCu-DA) 作为一个有效的诱导器的ICD.
研究FeCu-DA与抗PD-L1疗法的协同效应,以加强癌症治疗.

主要方法:

制造和表征FeCu-DA纳米酶.
评估过氧化酶 (POD),催化酶和谷氨氧化酶 (GSH-OXD) 的活性.
评估ICD诱导和抗瘤疗效与抗PD-L1和近红外辐射相结合.

主要成果:

FeCu-DA证明了协同的POD和触酶活动,有效地将H2O2转化为OH和O2.
FeCu-DA表现出优越的GSH-OXD活性,使得持续的OH生成和克服ROS电阻.
动力分析和DFT计算显示,FeCu-DA的催化效率比Fe单原子纳米酶更高.
在NIR照射下,FeCu-DA诱导了强烈的ICD,并与抗PD-L1阻塞具有协同治疗效应.

结论:

FeCu-DA作为一种高效的双原子纳米酶,用于诱导ICD.
这项研究为癌症免疫治疗中先进的纳米酶提供了设计策略.
FeCu-DA对增强抗瘤免疫力和治疗瘤具有显著的潜力.

关键词:

癌症免疫疗法免疫疗法级联催化反应的催化剂.双原子纳米酶是一种双原子纳米酶.免疫原性细胞死亡光热疗法是一种光热疗法.

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