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现型年龄与肥胖个体的死亡风险之间的关联:一个回顾性队列研究
Yingxuan Huang1, Apei Zhou1, Yisen Huang1
1Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, China.
Frontiers in public health
|December 24, 2024
概括
现型衰老加速 (PAA) 显著预测肥胖成年人的死亡率. 较高的PAA表明所有原因,心血管和癌症死亡的风险增加,为健康管理策略提供信息.
科学领域:
- 生物医学科学 生物医学科学
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 肥胖是一个主要的全球健康问题,与增加的死亡率有关.
- 现型年龄加速 (PAA) 是衡量生物衰老相对于时间年龄的指标,已成为健康状况的潜在生物标志物.
- 特别是在肥胖人口中,PAA与死亡率之间的关联需要进一步研究.
研究的目的:
- 调查表型衰老加速 (PAA) 和全因死亡率之间的关联.
- 检查PAA和特定原因死亡率之间的关系,包括心血管和癌症死亡,在肥胖个体中.
- 为了确定PAA是否可以作为这个人口群体中死亡率的独立预测因素.
主要方法:
- 在国家健康和营养检查调查 (NHANES) (1999-2018) 中利用了9925名肥胖成年人 (BMI ≥30 kg/m2) 的数据.
- 使用临床生物标志物评估PAA,将其定义为表型年龄超过时间年龄.
- 采用卡普兰-梅尔生存分析和调整的考克斯比例危险模型来分析死亡风险,控制共变量.
主要成果:
- 在平均10.6年的随访期间,死亡人数为1537人,其中419人死于心血管疾病,357人死于癌症.
- PAA与所有原因死亡率 (HR = 1.84),心血管死亡率 (HR = 1.86) 和癌症死亡率 (HR = 1.47) 的风险增加有显著关联.
- 这些关联在调整多个混变量后仍然具有统计学意义,灵敏度分析证实了这些强有力的发现.
结论:
- 现型年龄加速 (PAA) 是肥胖个体全因,心血管和癌症死亡率的独立预测因素.
- 在肥胖人口中,PAA为死亡风险分层和指导健康管理干预提供了宝贵的见解.
- 这项研究强调了PAA在评估肥胖患者长期健康结果方面的临床实用性.
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