空气污染和血清维生素D水平之间的关系:系统性审查和元分析
Bahar Golastani1, Parinaz Poursafa2, Maryam Zarean1,3
1Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Advanced biomedical research
|December 24, 2024
概括
空气污染与体内维生素D水平降低有关. 这一系统性审查发现了显著的反相关性,表明空气质量影响维生素D状态,并可能增加缺乏症风险.
科学领域:
- 环境健康 环境健康
- 营养科学 营养科学
- 皮肤病学 皮肤病学
背景情况:
- 大气污染物可能会干扰皮肤中的维生素D代谢.
- 之前关于空气污染对血清维生素D水平的影响的研究产生了不一致的结果.
- 进行了系统性审查,以澄清空气污染和维生素D状态之间的关系.
研究的目的:
- 系统地审查和综合有关空气污染对维生素D水平影响的证据.
- 确定空气污染暴露是否与血清维生素D度的改变有关.
- 调查空气质量与维生素D缺乏之间的潜在联系.
主要方法:
- 在主要数据库 (PubMed,科学网,Scopus,谷歌学者) 进行了全面的文献搜索,截至2020年7月.
- 包括的研究是观察性,以人为基础,并以英语出版,评估空气污染对维生素D的影响.
- 来自26项研究的数据被系统地审查,其中5项研究被纳入了元分析.
主要成果:
- 分析显示,空气污染暴露与较低的维生素D水平之间存在显著的关联 (整体平均差异 = -8.04).
- 在包括的研究中观察到相当大的异质性 (I2 = 91.39%).
- 对空气污染的暴露始终与血清维生素D度降低有关.
结论:
- 空气污染水平与维生素D状况之间存在明显的反向相关性.
- 空气污染物可以阻碍太阳紫外线B (UVB) 辐射的透,这对于皮肤中维生素D的合成至关重要.
- 增加的空气污染可能会导致维生素D缺乏的更高的患病率.
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