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基于尿液和血清生物标志物的糖尿病病早期检测:最新的系统性审查

Farzaneh Karimi¹, Mostafa Moazamfard², Rasul Taghvaeefar³

¹Department of Physiology, Behbahan Faculty of Medical Sciences, Behbahan, Iran.

Advanced biomedical research

|December 24, 2024

概括

新的生物标志物在2型糖尿病 (T2DM) 患者中对早期糖尿病病 (DN) 检测有希望. 识别这些标志物有助于及时干预,可能减缓慢性病的进展.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
生物标志物发现发现

背景情况:

糖尿病病 (DN) 是慢性病 (CKD) 和2型糖尿病 (T2DM) 患者末期病的主要原因.
目前的诊断方法,如白蛋白尿和血清肌素,可能无法检测早期损伤.
早期检测和干预对于管理DN进展和改善患者结果至关重要.

研究的目的:

系统地审查血清和尿路生物标志物的诊断价值,以便在T2DM患者中早期检测DN.
确定有前途的生物标志物,可以帮助早期诊断和干预.
探索组合生物标志物方法的潜力,包括遗传和mRNA标志物.

主要方法:

一个系统的文献审查涉及人类人口的观测研究.
在主要的科学数据库 (PubMed,Scopus,Web of Science) 进行的搜索.
不包括动物和体外试验研究.

主要成果:

一些血清生物标志物,包括内特林-1,骨质,阿迪波内克丁,IL-6和IL-8,显示了早期DN检测的潜力.
尿路生物标志物,如中性粒细胞凝酶相关的卡林 (NGAL),转激素,N-乙-β-D-葡萄糖胺酶 (NAG) 和细胞因子是可靠的指标.
结合血清和尿路生物标志物可能会提高诊断准确度.

结论:

新的血清和尿路生物标志物可以改善T2DM中糖尿病病的早期检测.
将这些生物标志物纳入临床实践可以促进早期诊断和管理.
未来的研究可以探索组合生物标记器策略,包括遗传和mRNA标记器,以进行全面的DNA评估.

关键词:

生物标志物生物标志物糖尿病糖尿病患者糖尿病患者糖尿病性脏病糖尿病性脏病审查审查审查审查审查审查

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