细菌生物膜:在医疗保健系统中的形成,影响和可能的管理目标
Eric Omori Omwenga1, Silas Onyango Awuor2,3
1Department of Medical Microbiology & Parasitology, School of Health Sciences, Kisii University, Kisii, Kenya.
概括
细菌生物膜是难以治疗的感染和抗菌素耐药性 (AMR) 的主要原因. 了解生物膜的形成是开发抗药性病原体的新策略的关键.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 多种耐药性病原体的数量正在增加,需要新的抗病毒策略.
- 生物膜形成是一个关键的细菌毒性因素,使感染管理复杂化并促进慢性感染.
- 自从最早的 prokaryotes 以来,生物膜一直存在,随着时间的推移,科学理解越来越大.
研究的目的:
- 审查生物膜形成作为毒性因子的作用.
- 探索生物膜对抗菌素耐药性的影响 (AMR).
- 为了突出治疗生物膜相关感染的挑战.
主要方法:
- 关于生物膜形成及其与毒性和AMR的联系的文献综述.
- 分析生物膜特征及其对治疗耐药性的贡献.
- 探索影响生物膜形成的因素,如定数感应.
主要成果:
- 细菌生物膜创造了独特的微环境,降低了抗生素的疗效.
- 生物膜使细菌能够逃避宿主免疫反应.
- 生物膜的形成是通过定数感应,营养减少和恶劣的环境条件来增强的.
结论:
- 愈来愈多的耐治疗生物膜感染在医学和农业中带来了重大挑战.
- 需要进一步的研究才能充分理解生物膜形成的机制.
- 针对生物膜形成提供了一种潜在的策略来打击抗微生物药物耐药性.
相关概念视频
Bacterial Signaling
30.6K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
30.6K
Healthcare Associated Infections II: Preventive Measures
2.3K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.3K
Issues And Trends In Healthcare Delivery System
5.5K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
5.5K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
3.8K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
3.8K


