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奎尔素通过抑制CXCL8-CXCR1/2轴:网络和转录组分析来缓解性结肠炎

Zhangyu Jiang¹, Mingjuan Yan², Yanmi Qin³

¹International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

Frontiers in pharmacology

|December 24, 2024

概括

奎尔素通过减少炎症和修复肠道屏障,有效地治疗小鼠的性结肠炎 (UC). 它针对CXCL8-CXCR1/2信号通路,为新的UC疗法提供了潜力.

科学领域:

胃肠道学和免疫学
药理学和自然产品的研究.

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病,其特点是肠道受损.
粘膜愈合是UC治疗成功的关键指标.
奎尔是一种天然的黄类化合物,具有抗炎和抗氧化特性.

研究的目的:

在性结肠炎 (UC) 的小鼠模型中研究素的治疗潜力.
阐明瑞在UC中的作用的潜在分子机制.

主要方法:

综合网络预测和转录基因分析,以确定UC中的Quercetin目标.
使用硫酸德克斯 (DSS) 诱导的UC小鼠模型.
评估了病理形态,炎症标志物和粘膜屏障蛋白.

主要成果:

网络分析确定CXCL8-CXCR1/2轴是UC的一个关键目标.
奎尔丁治疗改善了DSS诱导的大肠炎症状,恢复了结肠结构并减少了炎症.
奎尔素通过增加紧结蛋白表达和减少炎症媒介 (IL-17A,NF-κB,CXCL8,CXCR1,CXCR2) 来增强肠道屏障完整性.

结论:

奎尔在UC的小鼠模型中显示出显著的治疗效果.
抑制CXCL8-CXCR1/2信号通路是奎尔塞丁有效性的关键机制.
这些发现支持克尔西用于治疗UC的临床应用和药物开发.

关键词:

在CXCL8-CXCR1/2轴上肠道粘膜障碍物肠道粘膜障碍物网络分析网络分析文素 (Quercetin) 是一种文素.转录组 (transcriptome) 是一个转录组.性结肠炎是一种

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