相关实验视频

Updated: May 8, 2025

3D Ultrasound Imaging: Fast and Cost-effective Morphometry of Musculoskeletal Tissue

3D Ultrasound Imaging: Fast and Cost-effective Morphometry of Musculoskeletal Tissue

Published on: November 27, 2017

肌肉缩和COPD患者的死亡风险之间的关联:系统性审查

Wenyan Li^1,2, Ying Wu³, Xun Yang¹

¹Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Therapeutic advances in respiratory disease

|December 24, 2024

概括

慢性阻塞性肺病 (COPD) 患者的肌肉缩显著增加死亡风险. 这一系统性审查强调了肌肉消耗和COPD的较差结果之间的关联,强调需要进一步研究.

科学领域:

肺部病理学肺部病理学
老年病的医生老年病的医生
临床医学临床医学

背景情况:

肌肉缩是晚期慢性疾病的常见并发症,对患者的治疗结果产生负面影响.
慢性阻塞性肺病 (COPD) 患者的肌肉缩和死亡率之间的关系尚不清楚.
这项研究旨在澄清肌肉缩对COPD患者死亡率的影响.

研究的目的:

系统评估COPD诊断患者肌肉缩和死亡率之间的关联.
综合现有关于肌肉缩在COPD的预后影响的证据.

主要方法:

进行了对队列研究的系统审查和元分析.
进行广泛的数据库搜索 (PubMed,科学网,Embase等) 进行到2023年7月1日.
分析了13项涉及10,528名COPD患者的队列研究的数据,其中7项研究被纳入了元分析 (3,458名患者).

主要成果:

分析显示,肌肉缩的COPD患者的死亡风险明显更高 (HR=2.20,95% CI [1.74,2.79],p<0.00001).
患有COPD和肌肉缩的患者也可能经历更长的住院时间.
包括13项队列研究,共包括10528名COPD患者.

结论:

肌肉缩明显与COPD患者的死亡率增加和疾病预后较差有关.
这些发现强调了在COPD管理中解决肌肉缩的临床意义.
建议进行进一步的高质量研究来验证这些结论,因为包含的文章数量有限.

关键词:

萨尔科佩尼亚是什么意思萨尔科佩尼亚慢性阻塞性肺病慢性阻塞性肺病死亡率死亡率肌肉缩肌肉缩肌肉缩系统性审查系统性审查

更多相关视频

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

相关概念视频

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

Chronic Obstructive Pulmonary Disease-V: Management

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

Cross-bridge Cycle

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation