新证据表明,巴罗反射和呼吸化学反射介导的大脑交感激活在人类
Michael M Tymko1,2, Audrey Drapeau3,4, Maria Augusta Vieira-Coelho5,6
1Integrative Cerebrovascular and Environmental Physiology SB Laboratory, Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, Ontario, Canada.
大脑中的交感神经活动随着呼吸挑战和压力变化而增加,但这不会影响内动脉的血液流动. 这项研究阐明了大脑对生理压力因素的反应.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 自主神经系统的自主神经系统
背景情况:
- 大脑的交感内接是广泛的,但它的生理作用仍然不清楚.
- 了解大脑交感神经活动 (SNA) 对于理解大脑功能和调节至关重要.
- 以前的研究还没有完全阐明巴罗反射和化学反射激活对大脑SNA的影响.
研究的目的:
- 为了研究假设,单边大脑上腺素 (NE) 溢出,大脑SNA的指数,在巴罗反射和呼吸道化学反射刺激期间增加.
- 检查下体负压 (LBNP) 和二氧化碳 (CO2) 管理对大脑SNA的独立和联合影响.
- 为了确定大脑SNA的变化是否与内动脉血流的变化相关.
主要方法:
- 在12名健康参与者中同时采集动脉和内静脉血液样本.
- 输入三化NE以测量NE溢出.
- 在LBNP和CO2挑战期间使用双重超声波测量脑血流.
主要成果:
- 单边大脑NE溢出显著增加高头 (CO2管理) 和结合LBNP (-40 Torr) +CO2.
- 单独使用LBNP时,没有观察到单边大脑NE溢出的显著变化.
- 总NE溢出和内动脉血流不受应用于压力因素的影响.
结论:
- 巴罗反射和呼吸道化学反射激活刺激大脑SNA.
- 测量的脑交感激活不会影响内动脉血流调节.
- 这项研究为在生理压力下大脑自主控制机制提供了新的见解.
更多相关视频
06:30Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
Published on: September 11, 2018
11:34Breathing-controlled Electrical Stimulation BreEStim for Management of Neuropathic Pain and Spasticity
Published on: January 10, 2013
相关概念视频
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Regulation of the Cardiovascular System
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
Physiology of Respiration II: Neurogenic Control of Respiration
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Chemical Factors Affecting Respiration Centers
CO2 has a potent influence on respiration and is strictly regulated....
Sympathetic Activation
Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
