Jove
Visualize
联系我们

相关概念视频

Drug Delivery: Overview01:16

Drug Delivery: Overview

276
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
276
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

315
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
315
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

411
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
411
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

377
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
377
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

1.9K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.9K
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

422
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
422

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance.

Cell·2026
Same author

Confinement and Interface Effects on Radiolysis in Liquid-Phase TEM Probed by Palladium Nanocrystal Etching.

Nano letters·2026
Same author

Complete plastid and mitochondrial genomes of the coralline marine red algae <i>Chiharaea americana</i> f. <i>americana</i> and <i>C. americana</i> f. <i>bodegensis</i> (Corallinaceae, Rhodophyta).

Microbiology resource announcements·2026
Same author

Boosting ionic conductivity of single-ion conductive polyelectrolyte elastomers via high-dielectric plasticizers.

Nature materials·2026
Same author

Enhanced electrical performance of tellurium FETs via ultra-thin atomic-layer-deposited Al<sub>2</sub>O<sub>3</sub>interlayer for Fermi-level de-pinning.

Nanotechnology·2026
Same author

Inverse-scattering of absorptive samples via beam propagation.

bioRxiv : the preprint server for biology·2026
Same journal

Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Advanced Electrolyte Materials Design for High-Energy Lithium Metal Batteries Beyond 500 Wh Kg<sup>-1</sup>.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Hydrophilic-Stable Nucleoside-Based Hydrogen-Bonded Organic Frameworks (N-HOF) for Therapeutic Bacterial Hybrid Systems.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Lanthanide-Bridged Dual-Atom Catalysts for Efficient Chlorine Electrosynthesis.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Composite Liquid Marble Templated Millimetric Capsule With Tunable Rigidity, Porosity, and Thermal Reconfigurability Toward 3D Cell Culture.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Bias-Triggered Conductivity Relaxation (BCR): A Unique Tool to Simultaneously Investigate Thermodynamics, Kinetics, and Electrostatic Effects of Oxygen Reactions in MIEC Thin Films.

Advanced materials (Deerfield Beach, Fla.)·2026
查看所有相关文章
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 4, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.5K

基于离子二极管的药物输送系统

Hyunjae Yoo1, Soon-Bo Kang1, Jeongsoo Kim2

  • 1Department of Material Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.

Advanced materials (Deerfield Beach, Fla.)
|December 24, 2024
PubMed
概括
此摘要是机器生成的。

一种新的离子二极管药物递送系统可以控制细胞毒药物的持续释放,提高抗瘤疗效,并在临床前模型中降低毒性.

关键词:
积极的药物输送系统.这是一个自由流动的自由流动.基于水凝的设备是基于水凝的设备.免疫毒性 免疫毒性离子二极管是一种离子二极管.

更多相关视频

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

10.9K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.7K

相关实验视频

Last Updated: Jun 4, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
10:16

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

7.5K
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

10.9K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.7K

科学领域:

  • 生物医学工程 生物医学工程
  • 材料科学 材料科学 材料科学
  • 在瘤学瘤学.

背景情况:

  • 传统的药物输送系统在与细胞毒性药物的空间时间控制和持续释放作斗争.
  • 实现精确的药物释放对于最大限度地提高疗效和最大限度地减少非目标组织损伤至关重要.

研究的目的:

  • 开发和评估一种基于电位控制的离子二极管的药物输送系统,用于持续和局部的药物释放.
  • 在临床前瘤模型中评估该系统的抗瘤疗效和安全性.

主要方法:

  • 一个离子二极管系统被设计用于通过电势控制药物释放 (纳米到微克尺度).
  • 该系统使用水凝来缓慢,连续地将药物扩散到目标部位.
  • 该装置植入了一个自由移动的携带瘤的小鼠模型中,并加载了多克索鲁比辛.

主要成果:

  • 离子二极管系统证明了持续的,无流量药物输送,在长时间内泄漏最小.
  • 在体内研究表明,与内注射相比,通过系统输送的多克索鲁比辛的抗瘤疗效优越.
  • 该系统表现出最小的非目标免疫毒性,突出其安全性.

结论:

  • 离子二极管药物递送系统为控制和持续释放细胞毒剂提供了一个有希望的平台.
  • 该系统的生物兼容性和机械兼容性支持其在治疗手术无法切除的瘤方面的临床转化潜力.