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修改后的银纳米粒子浸载体系统的抗微生物和抗癌潜力的评估

Ebru Kilicay¹, Ebru Erdal², Özge Kübra Karadag³

¹Department of Medical Laboratory Techniques, Şabanözü Vocational School, Çankırı Karatekin University, Cankiri, Turkey.

Journal of microencapsulation

|December 24, 2024

概括

装有银,咖啡酸和四环素的新纳米颗粒显示出治疗骨感染和癌症的前景. 这些药物输送系统为骨缺陷治疗提供了潜在的新疗法.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

骨缺陷在临床实践中存在重大挑战,通常需要治疗并发性感染和瘤疾病.
开发有效的药物输送系统对于本地化和持续的治疗作用在骨缺陷管理中至关重要.

研究的目的:

合成和描述用于治疗骨缺陷的新型纳米颗粒 (NP),其中包括银纳米颗粒 (AgNP),咖啡酸 (Caff) 和四环素化物 (TCH).
评估这些多功能NP在骨缺陷中联合感染和癌症治疗的治疗潜力.

主要方法:

通过自由基聚合,合成了poly (?? 烯酸) -poly (甲基甲酸) -poly (乙烯基醇) 的区块共聚合物.
使用溶剂蒸发方法制备纳米粒子 (NP),并使用FTIR,HNMR,SEM,DSC,TGA和DLS进行表征.
进行了药物负载 (LE),封装效率 (EE),抗菌活性,细胞毒性和体外释放研究.

主要成果:

合成的NP显示尺寸为198±2.89nm,尺寸分布窄 (PDI<0.1) 和负泽塔电位 (-27.5±0.13mV).
咖啡酸的高封装效率得到了实现 (73-78%).
卡夫NP表现出延长释放特征和针对测试病原体的显著抗菌活性,以及在SaOS细胞中显著的细胞毒性.

结论:

开发的TCH-Caff-AgNPsPRici-PMMA-PEGNP显示出作为治疗骨缺陷的多功能治疗剂的巨大潜力.
这些纳米颗粒在骨缺陷治疗中提供了一种有前途的策略,可以同时解决感染和癌症,因此需要进一步研究.

关键词:

农产品NP的使用方法在MCT3T3-E1上.这就是SaOS-2的原因.咖啡酸是一种咖啡酸.聚乙烯糖醇 (PEG) 是一种聚甲基酸) 是一种聚甲基酸.里辛酸乙酸是什么里辛酸乙酸是什么四环素化物四环素化物

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