Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Lung Capacity01:47

Lung Capacity

49.3K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
49.3K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.7K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Pleiotropy01:33

Pleiotropy

39.7K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
39.7K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

231
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
231
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

348
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
348

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Characterization of mucus plugging in patients with chronic obstructive pulmonary disease: additional clinical significance of asthma-like features.

BMC pulmonary medicine·2026
Same author

How the Exposome Shapes Our Respiratory Health.

American journal of respiratory and critical care medicine·2026
Same author

Use of the Wnt/β-catenin Activator Lithium Is Associated with Less Emphysema.

Annals of the American Thoracic Society·2026
Same author

Performance of Lung Cancer Risk Prediction Models in Different Racial and Ethnic Groups in the United States: Results From the Lung Cancer Cohort Consortium.

Annals of internal medicine·2026
Same author

SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles.

Communications biology·2026
Same author

COPD Strategies Across Countries and the Project for COPD MOrtality REduction BY 2032 (COMORE-By2032) in Japan.

Internal medicine (Tokyo, Japan)·2026
Same journal

Utility of Urine-Derived Cells for Characterizing Aberrant Splicing Caused by a Novel Deep Intronic L1CAM Variant.

Annals of human genetics·2026
Same journal

Distribution of HLA-DRB1 Alleles and Genotypes With Respect to Plasma Anti-SARS-CoV-2 IgG Titres Among COVID-19-Vaccinated Bangladeshi Adults.

Annals of human genetics·2026
Same journal

FIGLA Novel Variant c.385-9G>A Affects RNA Splicing in a Minigene Assay.

Annals of human genetics·2026
Same journal

Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk.

Annals of human genetics·2026
Same journal

Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis.

Annals of human genetics·2026
Same journal

A Novel Biallelic REL Frameshift Variant p.(Tyr9Ilefs*2) Causing Immunodeficiency-92 With Profound c-Rel Deficiency.

Annals of human genetics·2026
查看所有相关文章

相关实验视频

Updated: Jun 4, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

377

确定肺功能与牛皮之间的遗传联系

Kazuya Tanimura1,2, Melinda C Aldrich3, James Jaworski3

  • 1Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Annals of human genetics
|December 24, 2024
PubMed
概括
此摘要是机器生成的。

这项研究发现了牛皮和肺功能之间的遗传联系,确定了影响这两种疾病的特定单核酸多态 (SNP). 这些发现表明,皮肤和肺部健康的共同遗传基础,可能涉及免疫系统调节.

关键词:
伴随性疾病发生率.多形态主义的多态主义.牛皮是一种牛皮.一个单核酸的核酸.螺旋测量是一种螺旋测量.

更多相关视频

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

10.6K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

10.9K

相关实验视频

Last Updated: Jun 4, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

377
Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

10.6K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

10.9K

科学领域:

  • 遗传学和免疫学 遗传学和免疫学
  • 肺部病理学 肺部病理学
  • 皮肤病学 皮肤病学

背景情况:

  • 连接牛皮和肺部疾病的遗传基础在很大程度上仍未被探索.
  • 牛皮是一种自身免疫性疾病,具有潜在的全身影响.
  • 肺部并发症在牛皮患者中越来越多地被认可.

研究的目的:

  • 为了研究牛皮和肺功能之间的共同遗传因素.
  • 为了确定与牛皮和肺功能参数相关的特定单核酸多态 (SNP).
  • 通过遗传分析探索潜在的"皮肤-肺轴".

主要方法:

  • 使用英国生物银行 (UKBB) 和范德比尔特大学医学中心生物银行 (BioVU) 数据进行的横截面研究.
  • 分析63种已知与牛皮相关的SNP与肺功能指标 (FEV1,FVC,FEV1/FVC比率) 的关联.
  • 根据年龄和性别进行统计调整,在独立的队列中进行验证.

主要成果:

  • 在调整后,31个与牛皮相关的SNP与牛皮有显著的关联.
  • 16个SNP与1秒内强制呼气量 (FEV1) 相关,14个与强制生命能力 (FVC) 相关,以及5个与UKBB的FEV1/FVC比率相关.
  • SNP rs8016947小等位基因与减少牛皮风险和改善FEV1相关; rs17716942和rs8016947小等位基因与减少牛皮风险和增强FVC相关.

结论:

  • 确定了桥梁牛皮和肺功能遗传变异,表明共享的遗传基础.
  • 与这些变异相关的IFIH1,GCA和NFKBIA等基因调节先天免疫力.
  • 这些发现支持了"皮肤-肺轴"的假设,即免疫失调会影响皮肤和肺部健康.