在喘和慢性阻塞性肺病中评估肺透气和支气管扩展器反应,使用FMRI
Benjamin J Pippard1, Mary A Neal1, Charlotte W Holland1
1From the Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom (B.J.P., M.A.N., C.W.H., A.J.S., P.E.T.); Newcastle Magnetic Resonance Centre, Health Innovation Neighbourhood, Newcastle University, Newcastle upon Tyne NE4 5PL, United Kingdom (B.J.P., M.A.N., C.W.H., P.E.T.); Pulmonary, Lung and Respiratory Imaging Sheffield, Section of Medical Imaging and Technologies, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom (A.M.M., J.M.W.); Department of Respiratory Medicine, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom (I.F.); Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom (R.A.L.); Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom (H.F.F., J.N.S.M.); and Insigneo Institute, University of Sheffield, Sheffield, United Kingdom (J.M.W.).
使用 perfluoropropane 的19 (19F) MRI 能够有效地评估喘和 COPD 患者的区域性肺透气. 这种先进的成像技术量化了通风缺陷及其在支气管扩展剂治疗后的改善.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 肺功能测试缺乏区域肺功能异质性信息.
- 19 (19F) 核磁共振与 perfluoropropane 提供了定量,局部的肺通风评估没有超极化.
- 需要先进的成像来评估呼吸道疾病的区域通风.
研究的目的:
- 为了评估区域性肺透气,使用吸入 perfluoropropane 的F MRI.
- 评估喘,COPD和健康参与者的通风特性.
- 在患有呼吸道疾病的参与者中量化评估支气管扩展剂反应.
主要方法:
- 展望性,双中心研究涉及喘,COPD和健康参与者.
- 参与者在吸入 perfluoropropane-oxygen混合物后接受了螺旋计,质子MRI 和F MRI.
- 透气缺陷百分比 (VDP) 由FMRI计算;测量为疾病群体的支气管扩展剂的重复后给药.
主要成果:
- 与健康参与者 (1.8%) 相比,F MRI衍生的VDP在COPD (27.2%) 和喘 (8.3%) 中显著增加.
- 支气管扩展剂的使用可使喘患者的VDP降低33%,慢性肺炎患者的VDP降低14%.
- 19FMRI对区域通风变化和支气管扩展剂反应表现出敏感性.
结论:
- 吸入 perfluoropropane 的F MRI 是评估区域肺透气的敏感工具.
- 该技术可以对喘和COPD的通风缺陷进行定量评估.
- FMRI有效量化了支气管扩展剂诱导的区域肺通风变化.
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