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通过多因素优化和相互作用分析,加强素纳米泡的配方和性能

Hema Kumar A V¹, Chamakuri Kantlam²

¹Bharatiya Engineering Science and Technology Innovation University (BESTIU), Anantapur, Andhra Pradesh, India.

Pharmaceutical development and technology

|December 24, 2024

概括

这项研究开发了Quercetin (QT) 装载的多乳酸同糖酸 (PLGA) 纳米泡来增强QT.

科学领域:

* 制药纳米技术 * 制药纳米技术
* 药物输送系统药物输送系统
* 聚合物科学聚合物科学

背景情况:

* 奎尔素 (QT) 是一种天然的黄类化合物,具有潜在的健康益处,但具有不良的溶解性和生物利用性.
* 传统的QT配方限制了其治疗疗效.
* 开发先进的输送系统对于改善QT的药物应用至关重要.

研究的目的:

* 合成,开发和优化聚乳酸同糖酸 (PLGA) 纳米气泡,以持续提供QT.
*为了提高奎尔的稳定性和生物可用性.
* 为了研究 QT 加载的 PLGA 纳米泡的物理化学性质和体内性能.

主要方法:

*用于纳米泡合成的溶剂蒸发方法.
*用于优化QT-PLGA纳米泡的Box-Behnken设计.
* 特性包括粒子大小,PDI,泽塔潜力,捕获效率,FTIR,DSC,XRD和SEM.

主要成果:

*优化的配方:50毫克QT,250毫克PLGA,1.89%PVA.
* 特性纳米泡:139.5 nm大小,0.296 PDI,-23.0 mV泽塔电位,59.24%的捕获效率.
* 没有证实药物-聚合物相互作用;在老鼠中证明了持续的*体外*释放,良好的稳定性和显著增加的*体内*Cmax和AUC0-t.

结论:

* QT加载的PLGA纳米泡成功改善了奎尔的持续释放和生物可用性.
*开发的纳米泡系统显示了提高药物动力学和治疗结果的前景.
*这种配方为奎尔塞丁的向药物输送应用提供了潜力.

关键词:

生物可用性生物可用性盒子-Behnken设计的设计.在 PLGA PLGA 中.这些是纳米泡.文素 (Quercetin) 是一种文素.药理动力学药理动力学

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