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中央和外围omega 3氧利平因对急性全身炎症的反应的性别差异
Julia C Kelliher1, Ivana Maric2, Christopher G Engeland3,4
1Integrative and Biomedical Physiology, The Pennsylvania State University, University Park, Pennsylvania, United States.
概括
性差异出现在身体如何处理炎症. 在女性中,急性炎症降低了抗炎omega-3氧利平的含量,这表明疾病期间大脑与身体的通信发生了变化.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 高密度脂蛋白 (HDL) 氧利平调节炎症,但它们对急性炎症和大脑信号的性别特异性反应尚不清楚.
- 尽管免疫反应更强,但女性的痴呆风险更高,暗示了基于性别的复杂炎症和神经相互作用.
研究的目的:
- 在炎症挑战后,研究血HDL和脑脊液 (CSF) 中氧利平因型的性别差异.
- 为了确定急性系统性炎症如何影响男性和女性的外周和中央氧利信号不同.
主要方法:
- 使用液体染色学与双重质谱学 (LC/MS/MS) 的向性脂组学.
- 在干白素-1β (IL-1β) 给药后,对雄性和雌性大鼠的血HDL和CSF中氧利平蛋白的分析.
主要成果:
- 介质素-1β (IL-1β) 在男性和女性的血HDL和CSF中改变了omega-6和omega-3氧利平.
- 女性在IL-1β后的血HDL和CSF中独特地显示了降低的全球氧利平度.
- 在女性中,度降低与抗炎omega-3eicosapentaenoic acid (EPA) 衍生型二氧乙酸乙酸 (DiHETEs) 的较低水平有关.
结论:
- 对急性炎症的性二态氧利平反应为免疫和神经炎症差异提供了分子洞察力.
- 在炎症大鼠中,血HDL和脑中EPA衍生的DiHETEs之间的相关性增加表明,在急性炎症期间,外围-大脑交叉声会增强.
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