在大鼠中评估酸对乙醇诱导的胃的保护作用
Fazile Nur Ekinci Akdemir1, Mustafa Can Güler2, Ersen Eraslan3
1Department of Nutrition and Dietetics, Faculty of Health Science, Ağrı İbrahim Çeçen University, Ağrı, Turkey.
Naunyn-Schmiedeberg's archives of pharmacology
|December 24, 2024
概括
酸 (SA) 通过减少氧化应激和炎症来保护免受乙醇诱导的胃. 这种天然化合物显示出作为治疗胃粘膜损伤的治疗剂的希望.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 生物化学 生化学
背景情况:
- 乙醇诱导的胃是一个重大的健康问题.
- 氧化应激和炎症在病原发生中起着至关重要的作用.
- 目前的治疗方法有局限性,需要新的治疗方法.
研究的目的:
- 在大鼠模型中评估酸 (SA) 对乙醇诱导的胃的保护作用.
- 研究SA对氧化应激和炎症标志物的影响.
- 为了比较SA与奥梅普拉 (OMEP) 的疗效.
主要方法:
- 在老鼠中由乙醇诱导的胃模型.
- 在14天内口服SA (20和40毫克/公斤) 或OMEP (20毫克/公斤).
- 评估生物化学标记物 (TAS,TOS,OSI,MDA,MPO),促炎细胞因子 (TNF-α,IL-1β,IL-6),以及通过ELISA进行的细胞灭亡,组织病理学和免疫组织化学.
主要成果:
- SA显著增强了总抗氧化剂状态 (TAS) 和减少了总氧化剂状态 (TOS),氧化应激指数 (OSI),马隆迪甲 (MDA) 和髓氧化酶 (MPO) 活性.
- 抗炎症治疗有效降低了促炎性细胞因子 (TNF-α,IL-1β,IL-6) 和巴克斯表达,减轻了炎症和亡.
- 抗胰岛素的保护作用与梅的保护作用相似.
结论:
- 酸在老鼠中显示出显著的保护作用,防止乙醇诱导的胃.
- SA通过改善氧化应激和炎症反应来发挥其治疗作用.
- 酸具有作为胃的新型治疗剂的潜力,需要进一步的临床研究.
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