抗血小板治疗与腰椎穿刺后并发症风险增加无关
Laura Stichaller1,2, Nik Krajnc1,2, Fritz Leutmezer1,2
1Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Journal of neurology
|December 24, 2024
概括
腰部穿刺 (LP) 后的并发症影响大约四分之一的患者,年龄较小和女性性别是关键的风险因素. 抗血小板治疗 (APT) 并没有增加并发症风险,这表明LP可以在接受APT的患者中继续治疗.
科学领域:
- 神经学 神经学
- 医疗程序 医疗程序
背景情况:
- 腰部穿刺 (LP) 对于诊断神经疾病至关重要.
- 潜在的并发症包括腹腔穿刺后头痛 (PDPH),背部疼痛,以及罕见的事件,如腹腔内血瘤或静脉鼻血栓形成.
- 抗血小板治疗 (APT) 对LP并发症率的影响仍然不确定.
研究的目的:
- 调查抗血小板治疗 (APT) 与腰椎穿刺 (LP) 后并发症风险之间的关联.
- 为了确定与LP并发症相关的患者人口统计和临床因素.
主要方法:
- 783名接受诊断LP的患者进行了回顾性观察性研究.
- 使用多变量逻辑回归分析来评估APT与并发症之间的关系,并对混因素进行调整.
- 包括PDPH和背部疼痛在内的并发症被记录和分析.
主要成果:
- 整体并发症率为23.2% (182/783名患者).
- 年龄较小 (OR 1.49) 和女性性别 (OR 1.74) 与并发症风险增加有显著关联.
- 抗血小板治疗 (APT) 与并发症风险增加没有显著关联 (OR 0.63,p=0.241).
结论:
- 大约四分之一的患者在LP后出现并发症.
- 年龄较小和女性性别被确定为LP并发症的重要风险因素.
- 这项研究表明,抗血小板治疗 (APT) 不会增加并发症的风险,这可能会减轻对服用这些药物的患者保留LP的担忧.
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