皮质大脑发育和完全智商的运动预测因子在极早出生的儿童中,有或没有离散的白质异常
L Fernández de Gamarra-Oca1, D Nosko2, H Kvanta3
1Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Bizkaia, Spain. lexuri.fernandez@deusto.es.
Brain structure & function
|December 24, 2024
概括
患有白质异常 (WMA) 的极度早产 (EPT) 儿童显示皮质大脑发育较厚. 早期的精细运动技能预测了WMA这些EPT儿童的全面智商.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 放射学 放射学是一门学科.
背景情况:
- 极度早产 (EPT) 出生 (怀孕27周以下) 对神经发育结果构成风险.
- 离散白质异常 (WMA) 在EPT幸存者中很常见,可能会影响大脑发育.
- 了解皮层发育和认知功能的预测因子,EPT儿童与WMA至关重要.
研究的目的:
- 为了研究皮质大脑发育和全尺度智商在学校年龄的孩子出生EPT,考虑WMA.
- 确定带有和没有WMA的EPT儿童皮质发育和智商的早期运动预测因素.
主要方法:
- 使用Freesurfer对51名EPT儿童和40名10岁对照者的皮质体积和厚度进行T1加权MRI分析.
- 在2.5岁时评估精细和粗运动功能 (BSID-III),在12岁时评估全尺度智商 (WISC-V).
主要成果:
- 带有和没有WMA的EPT儿童之间的运动功能或全尺度智商没有显著差异.
- 患有WMA的EPT儿童表现出更厚的双边平均皮质厚度,特别是在额叶和叶.
- 2.5年的精细运动障碍预测了WMA的EPT儿童全尺度智商变异的42.9%.
结论:
- 患有WMA的EPT出生儿童在10岁时表现出皮质厚度的改变.
- 早期的精细运动技能是WMA的EPT儿童以后全面智商的重要预测因素.
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