在接受bDMARDs的类风湿病患者中严重感染的频率:移植后的多中心研究
Tuba Demirci Yıldırım1, Emel Oğuz Kökoğlu2, Belkıs Nihan Coşkun3
1Department of Rheumatology, Faculty of Medicine, Dokuz Eylul University, İnciraltı Mahallesi Mithatpaşa Cad. no:1606, Balçova, İzmir, Türkiye. tubademirci87@gmail.com.
Clinical rheumatology
|December 24, 2024
概括
经过移植后接受生物治疗的类风湿病患者面临严重感染的高风险,包括尿路感染和肺炎. 密切监测对于管理这些风险至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 移植脏的接受者通常需要治疗类风湿性疾病.
- 生物疾病修饰性抗风湿药物 (bDMARDs) 用于风湿性疾病.
- 在移植患者中,bDMARDs在感染风险方面的安全性尚未得到充分确立.
研究的目的:
- 确定移植接受者治疗bDMARDs治疗风湿性疾病的严重感染的发病率和特征.
- 为了确定与这种患者群体中严重感染相关的潜在风险因素.
主要方法:
- 一项多中心的回顾性研究,涉及38名接受脏移植的接受者,接受bDMARD治疗风湿性疾病.
- 数据收集包括人口统计,临床信息和治疗细节.
- 严重感染被定义为需要住院治疗的严重感染;发病率计算为每100个患者年.
主要成果:
- 超过一半的患者 (52.6%) 患有严重感染,每100个患者年发生率为26.2例.
- 最常见的感染是尿路感染 (43.5%) 和肺炎 (30.8%).
- 家庭地中海热是主要的类风湿性疾病 (57.9%);IL-1抑制剂是最常见的bDMARDs (68.4%). 四名患者死于与感染有关的并发症.
结论:
- 用bDMARD治疗风湿性疾病的移植接受者存在严重感染的重大风险.
- 同时的免疫抑制疗法可能会加剧感染风险.
- 仔细监测和个性化治疗对于平衡治疗效益和传染风险至关重要.
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