探索肠道微生物组:癌症诊断,预后和治疗的潜在生物标志物
Eui-Jeong Han1, Ji-Seon Ahn1, Yu-Jin Choi1
1Gwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.
Biochimica et biophysica acta. Reviews on cancer
|December 24, 2024
概括
肠道微生物群,一个复杂的微生物生态系统,越来越多地与癌症有关. 研究正在确定可能驱动癌症发展的特定肠道微生物,为新的诊断和治疗策略铺平了道路.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群,包括数万亿个微生物,对人类健康至关重要.
- 肠道微生物群落不平衡的失生症与各种癌症有关,包括食道,肝脏,结肠,胰腺和胃肠道癌症.
- 影响癌症发展和进展的精确微生物菌株在很大程度上仍未确定.
研究的目的:
- 审查当前关于肠道微生物组在多种癌症类型中的作用的研究.
- 为了确定关键的肠道微生物标与癌症发展有关.
- 评估肠道微生物群作为癌症临床生物标志物和治疗策略的潜力.
主要方法:
- 关于肠道微生物组和癌症的最新研究结果的文献综述.
- 综合数据,将特定的肠道微生物组成与不同类型的癌症联系起来.
- 分析当前对微生物对癌症发病因子的影响的理解.
主要成果:
- 在患有各种癌症的患者中,肠道微生物组的组成发生了显著的改变.
- 特定的细菌物种及其代谢活动越来越多地被认为是导致癌症发病和进展的因素.
- 虽然关联是显而易见的,但确切的因果关系和特定的微生物点需要进一步调查.
结论:
- 肠道微生物组在癌症的发展和在多种癌症类型的进展中发挥着重要作用.
- 识别与癌症相关的特定肠道微生物特征有望为早期检测和向治疗提供希望.
- 进一步的研究对于验证肠道微生物组作为瘤学中的生物标志物和治疗途径的临床实用性至关重要.
相关概念视频
Serum Laboratory Studies, Stool Test, Breath Test
318
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
318
What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K


