最近被诊断患有2型糖尿病的个人中的YKL-40,心血管事件和死亡率:丹麦队列研究
Alisa D Kjaergaard1, Allan Vaag2, Verena H Jensen2
1Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
Diabetes research and clinical practice
|December 24, 2024
概括
炎症生物标志物YKL-40可以预测2型糖尿病患者的心血管事件 (CVEs) 和死亡率. 较高的YKL-40水平与心力衰竭,周围动脉疾病和癌症死亡率的风险增加有关.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 生物标志物研究 生物标志物研究
背景情况:
- 2型糖尿病与心血管事件 (CVEs) 和死亡率的风险增加有关.
- 炎症生物标志物在了解这些风险方面发挥着至关重要的作用.
- YKL-40是一种炎症生物标志物,其在2型糖尿病的预后价值需要进一步调查.
研究的目的:
- 调查炎症生物标志物YKL-40与各种心血管事件 (CVEs) 发生率之间的关联.
- 评估YKL-40对2型糖尿病患者全因,心血管和癌症死亡率的预后价值.
- 在这个人群中,将YKL-40与C反应蛋白 (CRP) 的预测性能进行比较.
主要方法:
- 一组11346名新诊断的2型糖尿病患者被跟踪了长达14年的时间.
- 基线YKL-40和CRP水平被持续测量和分析,并按百分点组进行分析.
- 考克斯回归模型被用来评估与心房动,缺血性中风,静脉血栓栓塞,心肌梗塞,心力衰竭,外周动脉疾病和死亡结果的关联.
主要成果:
- 升高的YKL-40水平与心房动,心力衰竭和外围动脉疾病的风险增加显著相关.
- YKL-40是所有原因,心血管和癌症死亡率的强有力的预测因素.
- 无论是YKL-40还是CRP都独立预测了心血管事件风险,CRP在心肌梗塞和心血管死亡率方面表现出优越性.
结论:
- 在2型糖尿病患者中,YKL-40是大多数心血管事件的宝贵预后生物标志物.
- YKL-40显示出更强的预后能力,对所有原因的死亡率,主要是由癌症相关的原因驱动.
- 这些发现强调了YKL-40在2型糖尿病患者的风险分层和管理策略中的潜在作用.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes: Symptoms, Diagnosis, and Complications
503
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
503
Dipeptidyl Peptidase 4 Inhibitors
167
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
167
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Oral Hypoglycemic Agents: Biguanides and Glitazones
168
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
168


