关于聚合物微针加载细胞近期进展的综述:设计策略,制造技术,透皮应用和挑战
Zixin Wang1, Dongmei Zhang2, Ningning Liu1
1School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China.
International journal of biological macromolecules
|December 24, 2024
概括
装有活细胞的微针系统 (MNs) 为精密医学和细胞疗法提供了有前途的方法. 本综述涵盖了用于治疗疾病的细胞微针 (CMN) 的进展,强调了它们的潜力和挑战.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 再生医学是一种再生医学.
背景情况:
- 装有活细胞的微针系统 (MNs) 正在成为精密医学的关键技术.
- 细胞疗法在有效的治疗和治疗结果方面面临着挑战.
研究的目的:
- 为提供基于MN的细胞输送策略的近期进展的概述.
- 概述细胞微针 (CMN) 的设计原理和结构功能关系.
- 讨论CMN用于精密治疗,特别是炎症性皮肤疾病.
主要方法:
- 关于MNs用于细胞输送的最新文献的综述.
- 对CMN的材料选择,形态设计和加工方法的分析.
- 系统地概述微结构设计规律和CMN设计原则.
主要成果:
- 总结了基于MN的细胞输送策略的最新进展.
- 概述了通过皮肤递送的微观结构设计和功能之间的关系.
- 讨论了CMN用于炎症性皮肤疾病治疗的代表性研究.
结论:
- CMN为细胞疗法提供了一个实用的解决方案,推进了精准医学.
- 在开发具有全面性质的CMN方面仍然存在挑战,例如机械强度和细胞活力.
- 这项工作为开发创新的细胞治疗工具提供了见解.
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