含有levofloxacin的类隐形眼镜材料用于眼部药物输送
Xuefang Guo1, Ying Sun1, Jing Qiao1
1College of Chemistry and Chemical Engineering, Southeast University, Nanjing, China.
Journal of biomaterials applications
|December 24, 2024
概括
一种新的微乳液浸泡方法提高了隐形眼镜中的药物负载,以改善眼科药物输送. 这种方法确保了持续的勒沃素释放,并保持了透镜的性能,提供了一个有前途的治疗选择.
科学领域:
- 眼科医生 眼科 眼科
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 型隐形眼镜 (SCL) 正在成为可控眼部药物输送系统.
- 对于SCLs,现有的药物加载方法存在药物吸收率低,复杂的程序和受损的透镜特性.
- 需要改进的方法来提高药物负载能力并保持SCL的性能.
研究的目的:
- 开发和评估一种有效的微乳液浸泡方法,以增加SCL的药物载荷能力.
- 为了研究药物负载,持续释放动力学,以及服用莱沃素的SCLs的抗菌疗效.
- 评估药物加载方法对SCLs物理和光学特性的影响.
主要方法:
- 利沃素 (LVF) 通过直接将其封装在微乳液中.
- 使用浸泡 (浸泡) 方法将LVF微乳液装入SCL中.
- 评估了药物载荷能力,释放动力学,对大肠杆菌和黄金杆菌的抗菌活性,以及透镜特性 (胀,机械,氧气透性,透射率,接触角度).
主要成果:
- 微乳液浸泡方法显著提高了SCL中的LVF负荷,达到216.32±1.15μg/镜片的最大值.
- 实现了LVF的持续释放,在10小时内释放了95.96%的LVF,随后的泄漏量可以忽略不计.
- 含有药物的SCL显示出对大肠杆菌和金黄色杆菌的有效杀菌特性,同时保持了透射率 (>95%),胀,机械强度和氧气透性等关键镜片特性.
结论:
- 微乳液浸方法是非常有效的改善levofloxacin负载和实现持续释放的隐形眼镜.
- 这种方法保留了隐形眼镜的基本性能特征,包括光学清晰度和舒适度.
- 开发的装有药物的SCL显示出在眼科治疗中使用的巨大潜力,提供了一个改进的药物输送平台.
相关概念视频
01:16Drug Delivery: Overview
276
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
276
01:29Drug Delivery: Parenteral Route
411
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
411
01:22Drug Delivery: Miscellaneous Routes
315
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
315