母亲系统性红斑狼和婴儿感染之间的关联:瑞典的一项基于人口的队列研究
Sofie A M Gernaat1,2, Julia F Simard1,3, Maria Altman1,4
1Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
BMJ open
|December 24, 2024
概括
患有全身性红斑狼 (SLE) 的母亲产生的婴儿面临更高的早期感染风险,特别是在前72小时内. 过早分娩对这些新生儿的感染风险增加有很大影响.
科学领域:
- 生殖医学 生殖医学
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 是一种可影响孕妇的自身免疫性疾病.
- 了解母亲SLE对后代健康的影响对于新生儿护理至关重要.
研究的目的:
- 为了调查与没有SLE的母亲出生的婴儿相比,患有SLE的母亲出生的婴儿的感染风险.
- 检查早产作为母亲SLE和婴儿感染之间的关联中介者的作用.
主要方法:
- 从2006年到2021年,瑞典进行了一项基于登记的队列研究.
- 包括SLE母亲的1248名婴儿和没有SLE母亲的34,886名婴儿.
- 通过医疗保健访问和抗感染药物处方评估感染风险,重点关注72小时,1个月和1年内的风险.
主要成果:
- 患有SLE的母亲产生的婴儿在前72小时内感染的风险显著增加 (RR 1.62).
- 第一年整体感染风险略高 (RR 1.09),而住院感染风险在不同组之间相似.
- 过早分娩介导了母亲SLE在头72小时内感染的影响的86%.
结论:
- 患有SLE的母亲的婴儿感染的风险增加在新生儿期早期 (3天) 最为明显.
- 过早分娩是解释这种早期感染风险的一个重要因素.
- 孕产妇SLE应该被认为是早期新生儿感染的风险因素,可能会影响产后出院决定.
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