在患有并发症的患者中治疗失脂血症是面临挑战的
Lisa Frühwald1,2, Peter Fasching1,2, Dobromir Dobrev3,4,5
15th Medical Department with Endocrinology, Rheumatology and Acute-Geriatrics, Vienna Health Association, Ottakring Clinic, Montleartstraße 37, 1160 Vienna, Austria.
本综述探讨了降脂药对肝病患者的益处和风险. 它强调需要更多的研究来指导肝脏和心血管疾病患者的治疗.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 肝酶升高往往导致停止服用降脂药物.
- 这可能会阻止患者获得心血管方面的好处.
- 在肝病患者中,这些药物的现实世界证据有限.
研究的目的:
- 审查关于降脂药在患有肝病患者的益处和风险的证据.
- 专注于这些药物的潜在肝脏相关副作用.
- 为治疗肝功能障碍患者提供指导.
主要方法:
- 在PubMed. 的文献搜索.
- 检查各种降脂剂的疗效和安全性.
- 专注于他类药物,ezetimibe,bempedoic酸,PCSK9抑制剂,纤维酸和icosapent乙烯.
主要成果:
- 由于依赖病例报告,评估药物诱导的肝毒性具有挑战性.
- 缺乏对先前存在的肝病进行降脂疗法的强有力的证据.
- 总结了有关降脂药物和肝脏健康的现有数据.
结论:
- 需要进一步的研究来优化治疗策略.
- 患有肝脏和心血管疾病并存的患者需要量身定制的方法.
- 平衡心血管保护和肝脏安全至关重要.
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