通过结构方程建模方法探索饮食炎症指数和NAFLD之间的联系
Azam Doustmohammadian1, Farhad Zamani1, James R Hébert2,3
1Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
Journal of health, population, and nutrition
|December 24, 2024
概括
与饮食相关的炎症在伊朗成年人中显著影响非酒精性脂肪性肝病 (NAFLD). 这种效应由高血压,CRP,糖尿病和脂质失调症介导,突出了NAFLD管理的关键联系.
科学领域:
- 代谢和营养流行病学
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD),也称为代谢功能障碍相关的脂肪性肝病 (MASLD),是一个日益严重的全球健康问题.
- 饮食模式和生活方式选择对于管理NAFLD至关重要.
- 了解饮食引起的炎症和NAFLD之间的联系对于公共卫生战略至关重要.
研究的目的:
- 研究伊朗成年人与饮食相关的炎症和NAFLD之间的关联.
- 探索高血压,C反应蛋白 (CRP),糖尿病和脂质失调症在这种关系中的调解作用.
- 使用结构方程建模 (SEM) 进行综合分析.
主要方法:
- 这项研究分析了Amol队列研究 (AmolCS) 中3110名伊朗成年人的数据.
- 使用能量调整的饮食炎症指数 (E-DII) 评分来评估饮食炎症潜力.
- 使用结构方程建模 (SEM) 来分析复杂的关联.
主要成果:
- 在总样本和男性中,在E-DII得分和NAFLD之间发现了显著的关联,由高血压和CRP介导.
- 在总样本和女性中,E-DII得分显著影响了NAFLD,糖尿病作为调解者.
- 脱脂症被确定为NAFLD的危险因素,并部分调解了高血压的影响.
结论:
- 饮食性炎症通过涉及高血压,CRP,糖尿病和脂质不良症的中介途径显著与NAFLD相关.
- 这些发现强调了伊朗成年人口中饮食,炎症和NAFLD之间的复杂关系.
- 建议在高风险群体进行进一步的纵向研究,以证实这些关联.
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