通过大型系统干预项目减少抗生素使用和经济节约
Puneet Jairath1, Michael Howard Goodstein1, Karli Unick2
1Division of Newborn Medicine, Department of Pediatrics, WellSpan York Hospital, York, PA, USA.
Clinical pediatrics
|December 25, 2024
概括
一项大规模的系统干预显著减少了新生儿早期发性败血症 (EOS) 风险的抗生素使用. 这种方法使抗生素暴露率降低了64%,并节省了成本,而EOS再入院率没有增加.
科学领域:
- 新生儿医学 新生儿医学
- 预防传染病 预防传染病
- 改善医疗保健系统的改善
背景情况:
- 患有早期性败血症 (EOS) 风险的婴儿经常接受抗生素治疗,导致潜在的不良影响.
- 临床上有必要减少新生儿的抗生素暴露,同时保持安全.
研究的目的:
- 实施和评估一项旨在减少高危新生儿抗生素使用的大型系统干预 (LSI).
- 评估LSI对暴露于抗生素的婴儿比例的影响.
- 确定干预的财务影响.
主要方法:
- 对2018年1月至2020年6月怀孕35周或以上的婴儿抗生素使用的回顾性分析.
- 在2019年1月至6月期间实施LSI,包括凯泽败血症计算器.
- 质量指标12个月前和干预后的比较.
主要成果:
- 干预后,抗生素使用减少了68%,婴儿暴露减少了64%.
- 观察到,每名处于危险状态的新生儿节省了697美元的成本.
- 在研究期间,没有发生EOS的再入院.
结论:
- 系统性LSI可以安全地实施,以减少新生儿的抗生素暴露.
- 这种干预措施可以显著节省成本,而不会损害患者对EOS的安全.
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