相关实验视频
Updated: May 8, 2025

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
[USP20在口腔状细胞癌中的表达和临床意义]
Xiao-Qi Zhai1, Bo Liu, Cheng-Yi Sheng
1Department of Maxillofacial Surgery, Jiamusi University Affiliated Stomatological Hospital. Jiamusi 154004, Heilongjiang Province, China.
乌比基特异蛋白酶20 (USP20) 在口腔状细胞癌 (OSCC) 中高度表达,与瘤分化和大小相关. 这表明USP20可能会加速口腔癌的生长.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种普遍存在的恶性瘤.
- 对于OSCC研究来说,了解像ubiquitin特定蛋白酶20 (USP20) 这样的分子标记物至关重要.
研究的目的:
- 研究USP20在OSCC中的表达水平.
- 分析USP20表达和OSCC患者临床病理参数之间的相关性.
主要方法:
- 利用TCGA数据库进行差异基因表达分析.
- 采用免疫组织化学染色来评估OSCC,相邻和正常组织中的USP20蛋白水平.
- 使用组织微阵列和统计分析,与临床病理特征相关的USP20表达.
主要成果:
- 与准癌和正常组织相比,OSCC组织中USP20表达显著增加 (P < 0.001).
- 较高的USP20表达与较差的瘤分化 (P < 0.05) 和较大的原发性瘤大小 (P < 0.01) 相相关.
- 在USP20表达水平和整体存活率或5年存活率 (P > 0.05) 之间没有发现显著的关联.
结论:
- 在OSCC中,USP20受到上调.
- USP20表达与关键的临床病理特征有关,包括分化和瘤大小,这表明在OSCC进展中发挥了作用.
- 需要进一步的研究来探索USP20在加速口腔癌生长中的作用.
更多相关视频
10:26RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
09:49Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
相关概念视频
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Abnormal Proliferation
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Pleiotropy
Targeted Cancer Therapies
There are several types of targeted therapies against...