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拜卡林和IR780彩色脂质体用于抗真菌和抗癌疗法

Chandra Lekha Putta¹, Hima Sree Buddhiraju¹, Dokkari Nagalaxmi Yadav¹

¹Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Hyderabad 502285, India.

ACS applied bio materials

|December 25, 2024

概括

这项研究开发了Baicalein和IR780彩色脂质体 (BIRLs) 用于治疗三阴性乳腺癌 (TNBC) 和真菌感染. BIRLs表现出协同的抗真菌和抗癌作用,提供了一个有前途的双作用纳米平台.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

三重阴性乳腺癌 (TNBC) 是具有攻击性的,并且经常与因免疫抑制而导致的疹等感染同时发生.
菌 (Candida albicans) 是一种常见的与恶性瘤相关的真菌病原体,对癌症患者构成重大挑战.

研究的目的:

开发和描述一个多功能纳米平台 (BIRLs) 用于TNBC和真菌感染的协同治疗.
评估BIRLs与光热疗法 (PTT) 结合的疗效,以提高治疗结果.

主要方法:

拜卡莱因 (B) 和NIR染料IR780 (IR) 通过化大豆酸胆共同装入脂质体.
BIRLs被测试为对抗Candida albicans的协同抗真菌活性.
在纤维细胞细胞系和斑马鱼胚胎中评估了生物相容性.
评估了2D和3D培养中的光热和光动力学效应,瘤切除,ROS生成和抗癌活性.

主要成果:

BIRLs显示出对Candida albicans.的显著协同抗真菌功效.
BIRLs表现出有前途的光热和光动力学效应,在NIR激光照射时增强瘤剥离和ROS生成.
试验室研究显示强烈的抗癌活性,抑制TNBC细胞的增殖和迁移.
BIRLs有效地抑制了真菌生长,解决了免疫功能受损的癌症患者常见的并发症.

结论:

BIRLs代表了一种具有双重治疗潜力的多功能纳米平台,用于协同的癌症治疗和抗真菌治疗.
这种纳米平台有望改善三阴性乳腺癌患者的治疗结果,特别是那些同时患有真菌感染的患者.

关键词:

IR780 化物化物它具有抗癌活性,具有抗癌活性.巴伊卡莱因 (Baicalein) 是一种植物.脂质体是一种脂质体.光动力学疗法是一种光动力学疗法.光热疗法是一种光热疗法.三重阴性乳腺癌是什么

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