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相关概念视频

Protein Glycosylation01:25

Protein Glycosylation

6.4K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
6.4K
Oligosaccharide Assembly01:24

Oligosaccharide Assembly

2.7K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
2.7K
Glycocalyx and its Functions01:14

Glycocalyx and its Functions

3.4K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
3.4K
Proteoglycans01:05

Proteoglycans

3.8K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.8K
Glycosaminoglycans01:23

Glycosaminoglycans

4.6K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
4.6K

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相关实验视频

Updated: May 8, 2025

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
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MicroGlycoDB:使用语义网络技术的微生物甘氨酸数据库.

Sunmyoung Lee1, Louis-David Leclercq2, Yann Guerardel2

  • 1Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo, Japan.

BBA advances
|December 25, 2024
PubMed
概括
此摘要是机器生成的。

微生物甘氨酸对宿主相互作用至关重要. 一个新的数据库,MicroGlycoDB,集成微生物糖化数据使用语义网络技术更容易访问和分析.

关键词:
数据整合数据集成数据库数据库数据库是一个数据库.葡萄糖基酶化是什么? 葡萄糖基酶化是什么微生物 微生物语义数据是指语义数据.

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科学领域:

  • 微生物学 微生物学
  • 葡萄糖科学 (Glycoscience) 是一种科学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 微生物表面糖结合物对于宿主微生物相互作用至关重要.
  • 了解微生物糖化是治疗和益生菌应用的关键.
  • 目前的甘氨酸信息在数据库和文献中是分散的.

研究的目的:

  • 开发一个集中的数据库,用于微生物糖化信息.
  • 从模型生物体中整合和结构化微生物甘氨酸数据.
  • 促进对微生物甘化过程和应用的研究.

主要方法:

  • 开发了MicroGlycoDB数据库.
  • 用语义网络技术用于数据表示.
  • 为机器可访问性提供基于本体学的数据结构.

主要成果:

  • 现在可以获得关键模型微生物的综合甘氨酸信息.
  • MicroGlycoDB提供结构化,机器可读的微生物甘氨酸数据.
  • 该数据库促进了数据共享和与其他生物资源的整合.

结论:

  • MicroGlycoDB解决了分散的微生物甘氨酸信息的挑战.
  • 语义数据表示增强了微生物学中的知识发现.
  • 该数据库作为扩展更多微生物的糖化信息的基础.