素修饰的纳米颗粒通过调节肠道微生物群和化疗来改善S180小鼠的瘤治疗
Rong Zhang1, Wenjuan Zhang1, Qiuhua Zhang1
1School of Life Science and Medicine, Shandong University of Technology, Zibo, 255000, People's Republic of China.
International journal of nanomedicine
|December 25, 2024
概括
这项研究合成了素修饰的纳米粒子 (Cur/Se) 用于癌症治疗,显示出增强的抗瘤活性和改善肠道微生物群平衡. 这些纳米粒子通过增强黄素来提供癌症治疗的有希望的方法.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 黄素表现出抗癌性质,但其生物可用性较差.
- 纳米粒子正在探索治疗应用.
- 开发新的药物输送系统对于有效的癌症治疗至关重要.
研究的目的:
- 使用绿色方法合成素修饰的 (Cur/Se) 纳米颗粒.
- 在体外和体内评估Cur/Se纳米颗粒的抗癌疗效.
- 研究Cur/Se纳米颗粒对肠道微生物群组成的影响.
主要方法:
- 黄素被用作减少和封闭剂来合成Cur/Se纳米粒子.
- 在体外细胞毒性使用MTT和CCK8测定对HeLa和S180瘤细胞进行了评估.
- 在体内抗瘤活性和肠道微生物群的变化使用16SrRNA测序进行了分析.
主要成果:
- 库尔/Se纳米粒子 (6.86nm) 显示持续的黄素释放和增强的激素清除活性.
- 库尔/塞纳米颗粒对瘤细胞的细胞毒性显著增加,并增加了ROS的产生.
- 在体内研究显示,54.33%的瘤抑制率和肠道微生物群组成的显著改变.
结论:
- 库尔/塞纳米粒子增强了黄素的生物活性和抗癌作用.
- 库尔/塞纳米颗粒通过肠道微生物群调节,证明了改善癌症治疗的潜力.
- 这项研究强调了结合素和纳米颗粒的协同治疗潜力.
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