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在试管婴儿/ICSI-ET过程中开发和验证胚胎细胞形成的临床预测模型
Xingnan Liu1, Jingyun Zhao1, Yi Zhang1
1Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Frontiers in endocrinology
|December 25, 2024
概括
这项研究开发了一种临床模型,用于预测IVF/ICSI-ET周期中的囊胞形成. 该模型准确预测胚胎发育,帮助临床决策,以改善体外受精结果.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 临床建模 临床建模
背景情况:
- 胚胎囊形成是体外受精 (IVF) 和细胞内精子注射 (ICSI) 周期中的关键步骤.
- 预测胚胎细胞发育有助于优化胚胎选择和提高怀孕率.
研究的目的:
- 创建和验证一个临床模型来预测胚胎细胞形成的概率.
- 确定在IVF/ICSI-ET周期中影响囊胞发育的关键因素.
主要方法:
- 从2020年6月到2024年3月,对4961个分裂期胚胎进行了回顾性分析.
- 数据分为培训 (70%) 和验证 (30%) 集.
- 单变量和多变量逻辑回归分析以确定预测因素.
主要成果:
- 关键预测因素包括授精方法,取出的卵细胞,前核形态,裂球数,胚胎对称性,碎片化和基底孕激素水平.
- 该模型表现出良好的预测能力,在训练组中,曲线下的面积 (AUC) 为0.742,在验证组中为0.729.
结论:
- 一个经过验证的临床名图可以预测胚胎细胞形成的概率.
- 这种工具有助于临床医生在IVF/ICSI-ET周期期间做出明智的决定.
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