在III-IV级膝关节骨关节炎中评估氧化应激和细胞免疫力
Mustafa Aydin1, Gulcin Alp Avci2, Ulku Irem Yilmaz3
1University of Health Sciences, Faculty of Gulhane Medicine, Department of Orthopedics and Traumatology, Ankara, Türkiye.
The archives of bone and joint surgery
|December 25, 2024
概括
骨关节炎患者显示氧化剂平衡受损,有利于自由基和细胞免疫力下降. 这些变化与疾病的严重程度相关,特别是在晚期膝关节关节炎阶段.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 骨关节炎 (OA) 是一种退行性关节疾病,其特征是软骨的分解和炎症.
- 放射分级系统,如凯尔格伦和劳伦斯,对于诊断OA严重程度至关重要.
- 氧化应激和细胞免疫与OA的发病有关,但它们的具体作用需要进一步阐明.
研究的目的:
- 调查晚期膝关节骨关节炎 (III-IV级) 患者的氧化应激标志物和细胞免疫状态.
- 探索影响OA疾病过程和治疗有效性的潜在风险参数.
- 用凯尔格伦和劳伦斯分级系统将生物化学发现与疾病严重程度相关联.
主要方法:
- 使用凯尔格伦和劳伦斯系统 (III-IV级) 进行膝关节骨关节炎的放射性评估.
- 在血液样本中测量总抗氧化状态 (TAS) 和总氧化应激 (TOS) 的光谱测量.
- 高性能液体染色学 (HPLC) 测量胺水平和评估硫化-硫化平衡.
主要成果:
- 与健康对照组相比,患有晚期OA的患者的总抗氧化剂状态 (TAS) 和本源醇水平显著降低.
- 在OA患者组中,二硫化物和新丁度显著升高.
- 组之间在总氧化应激 (TOS) 或氧化应激指数 (OSI) 中没有发现显著差异.
结论:
- 在晚期膝关节关节炎中,氧化剂平衡被破坏,转移有利于自由基.
- 细胞免疫力下降,由升高的新素和改变的硫化-硫化平衡表明,与炎症和OA疾病过程有关.
- 这些氧化和免疫标志物与骨关节炎的分期有直接的相关性,特别是在III-IV级膝关节OA中.
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