根据组织学亚型的卵巢癌发病率的全球模式和趋势:1988年至2017年的基于人口的分析
Yi-Fan Wei1,2, Li Ning3, Yi-Lin Xu1,2
1Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
EClinicalMedicine
|December 25, 2024
概括
卵巢癌的发病率在全球范围内有所不同,欧洲的发病率最高,非洲和亚洲的发病率最低. 血清性癌症是最常见的,但亚型和趋势的区域差异凸显了针对性预防策略的必要性.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 全球健康 全球健康
背景情况:
- 卵巢癌 (OC) 是一种异质的恶性瘤,在全球发生率上有显著的变化.
- 诊断标准和风险因素可能会影响OCD的发病率和亚型随时间的分布.
研究的目的:
- 分析卵巢癌及其组织学亚型的全球发病率模式和趋势.
- 识别OC和亚型频率的区域差异和时间变化.
主要方法:
- 在65个国家和40个国家分别分析了OC和亚型的发病率数据 (2013-2017年) 和趋势 (1988-1992年至2013-2017年).
- 数据来源于五大洲癌症发病率 (CI5 XII) 和CI5plus数据库.
- 计算了年龄标准化率 (ASR) 和年均百分比变化以评估发病率和趋势;计算了亚型比例相对于整体OC ASR.
主要成果:
- 经合组织的发病率显示出显著的区域差异,在东欧/中欧和非常高的HDI地区最高,在非洲,亚洲和中等HDI地区最低.
- 在全球范围内,OC ASR稳定,但在欧洲,美洲和大洋洲下降,而在日本和韩国增加.
- 血清性癌是全球最常见的亚型. 欧洲国家有更多的血清性癌瘤,而亚洲国家有更多的子宫内膜细胞和透明细胞癌. 血清性癌症和生殖细胞瘤的ASR增加,而粘膜性癌症和腺癌NOS下降.
结论:
- 在OC发病率和亚型的全球模式和趋势受到遗传和生殖因素的影响.
- 特定区域的预防策略和持续监测对于减轻全球卵巢癌负担至关重要.
相关概念视频
02:07Oogenesis
63.1K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.1K
01:26Ovaries
503
The ovaries are roughly the size of almonds and measure approximately 2 to 3 centimeters in length. These paired structures are situated within the pelvic region and are anchored by the mesovarium—a peritoneal extension that also connects them to the wider structure of the broad ligament. The support system extends to the suspensory ligament, housing blood and lymphatic vessels. In addition, the ovarian ligament tethers the ovaries to the uterus.
On the ovarian surface, a layer of...
On the ovarian surface, a layer of...
503