在Penaeus monodon中对氨-N压力的免疫和生理反应:一种多omics方法
Zhi Luo1,2, Falin Zhou1,3, Song Jiang1,3
1South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture and Rural Affairs, Guangzhou, China.
Frontiers in immunology
|December 25, 2024
概括
氨-N压力会损害的健康,导致肝损伤,破坏免疫和代谢功能. 这项研究揭示了帮助水产养殖管理的关键分子反应.
科学领域:
- 水生物质毒理学研究
- 甲动物生理学 甲动物生理学
- 环境压力反应环境压力反应
背景情况:
- 氨-N 是一种主要的水产养殖污染物,影响水生物种.
- 了解的压力反应对于可持续的水产养殖至关重要.
研究的目的:
- 调查氨-N对Penaeus monodon的压力影响.
- 分析生化,组织学,转录学和代谢学变化.
- 确定的压力反应的分子机制.
主要方法:
- (Penaeus monodon) 暴露于氨-N压力 (12 和 96 小时).
- 对氧化应激和代谢的生物化学测定.
- 肝大脑的组织学检查.
- 对基因表达和代谢物概况的转录和代谢组分析.
主要成果:
- 氨-N诱导显著的肝胰腺损伤 (缩,变形).
- 转录组学显示在细胞亡,免疫力和新陈代谢中基因表达发生改变.
- 代谢学揭示了核酸周转,抗氧化防御和代谢途径的破坏.
- 多方面的应激反应包括氧化应激,免疫激活和代谢障碍.
结论:
- 氨-N压力会触发的复杂分子反应.
- 研究结果提供了关于甲动物环境压力机制的见解.
- 确定监测和减轻水产养殖中的氨-N影响的潜在生物标志物.
相关概念视频
01:29Immune Response Against Viral Pathogens
449
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
449
01:21Introduction to Innate and Adaptive Immunity
3.2K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
3.2K
01:40Cell-mediated Immune Responses
65.1K
Overview
65.1K
01:27Allergic Drug Reactions
783
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
783
01:36Humoral Immune Responses
69.7K
Overview
69.7K
01:30Inflammatory Response I: Vascular and Cellular
10.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
10.5K