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在急性心肌梗塞患者中,BMI与特定原因的长期死亡率之间的关联
Timo Schmitz1, Dennis Freuer1, Philip Raake2
1Epidemiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
American journal of preventive cardiology
|December 25, 2024
概括
在急性心肌梗塞 (AMI) 后,较低或非常高的体重指数 (BMI) 会增加死亡风险. 25-30公斤/平方米之间的BMI与AMI后的最佳长期存活率有关.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 体重指数 (BMI) 是评估体重状况的常见指标.
- 急性心肌梗塞 (AMI) 后的BMI和死亡率之间的关系需要进一步调查.
研究的目的:
- 检查AMI时的BMI与长期全因和因特定死亡率之间的关联.
- 为了确定AMI后生存的最佳BMI范围.
主要方法:
- 来自奥格斯堡心肌梗塞登记处的10,651名住院AMI患者 (2000-2017年) 的分析.
- 利用多变量调整的COX回归模型与立方线来评估BMI和死亡率.
- 研究因特定死亡率 (心血管,缺血性心脏病,癌症) 并进行年龄分层子组分析.
主要成果:
- 在BMI和长期死亡率之间观察到显著的U形关联,BMI在25-30公斤/米2之间风险最低.
- 较低的BMI (<25 kg/m2) 始终与所有原因和群体的较高死亡率有关.
- 在60岁以下的患者中,BMI>35 kg/m2与全因死亡率的增加有关;这在老年患者中没有观察到.
结论:
- 在年轻患者 (<60岁) 中,低BMI和高BMI都是AMI后死亡的风险因素.
- 25-30公斤/平方米的BMI范围似乎是最有利于AMI后的长期存活.
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