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相关概念视频

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

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Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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相关实验视频

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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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通过白物质了解认知衰老:基于固定的分析.

Emma M Tinney1,2, Aaron E L Warren3, Meishan Ai1,2

  • 1Department of Psychology, Northeastern University, Boston, Massachusetts, USA.

Human brain mapping
|December 25, 2024
PubMed
概括

扩散权重成像 (DWI) 的基于固定的分析 (FBA) 显示了比传统方法更大的灵敏度来检测与年龄相关的白质变化及其对老年人的认知影响.

关键词:
酒后驾驶 酒后驾驶 酒后驾驶老化的老化 衰老的老化认知能力下降 认知能力下降基于fixel的分析分析白质是白色物质的组成部分.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经科学是一个神经科学.
  • 放射学 放射学是一门学科.

背景情况:

  • 扩散加权成像 (DWI) 对于研究与年龄相关的白质变化和认知衰退至关重要.
  • 传统的基于张数的分析难以解释复杂的白质结构,比如交叉纤维.

研究的目的:

  • 评估基于fixel的分析 (FBA),一种新的方法,对于检测与年龄相关的白质变化和认知关联,是否比基于张量分析更敏感.
  • 为了研究白质微观结构,衰老和老年人的认知表现之间的关系.

主要方法:

  • 研究了636名认知正常的成年人 (65-80岁) 使用扩散权重MRI.
  • 采用基于fixel的分析 (FBA) 来评估voxels中的纤维密度和横截面.
  • 将FBA发现与基于张量分析的传统voxel-wise分数异构 (FA) 进行了比较.

主要成果:

  • FBA揭示了年龄和纤维密度/横截面在,条状和胸膜通道的减少之间的显著关联.
  • 较低的纤维密度和横截面与较差的处理速度和注意力控制相关.
  • 以张量为基础的分析未能检测出与年龄或认知相关的显著白质变化.

结论:

  • 基于Fixel的分析 (FBA) 在检测老年人与年龄相关的白质变化方面表现出较高的灵敏度,与传统的基于张量的方法相比.
  • FBA可以揭示白质完整性和认知功能之间的临床相关联系,特别是处理速度和注意力.