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一个具有微波热效应的纳米温度计,用于检测细胞膜温度和测量微波诱导的热梯度分布
Nana Yin1, Chen Wei1, Yang Shu1
1Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.
Analytical chemistry
|December 25, 2024
概括
研究人员开发了一种新的纳米温度计,用于在微波 (MW) 热疗期间精确的纳米尺度温度控制. 该设备可以同时进行MW加热和准确的温度映射,这对于先进的医疗治疗至关重要.
科学领域:
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
背景情况:
- 在微波 (MW) 热疗中控制纳米尺度的温度是一个重大挑战.
- 精确的空间和时间温度监测对于有效的基于MW的处理是必不可少的.
研究的目的:
- 开发一种能够同时进行MW加热和纳米尺度温度测量的纳米温度计.
- 为了使细胞膜在MW加热过程中能够在现场感知温度.
主要方法:
- 通过使用乙烯基三甲基化物 (VBTMACl) 和异烯胺 (NIPAM) 的自由基聚合合成纳米温度计.
- 通过离子交换将酸3-(4-(1,2,2-triphenylvinyl) phenoxy) -1-硫酸盐 (TPESO3Na) 纳入.
- 利用聚合诱导排放 (AIE) 的微粒的自我组装来实现温度依赖的光.
主要成果:
- 纳米温度计在25-41°C范围内显示出优异的温度依赖的辐射,相对热敏度为8.3%°C-1在37°C.
- 纳米温度计的正电荷和两性质有助于细胞膜的定.
- 在MW加热过程中在细胞膜上实现了现场温度传感和分布映射.
结论:
- 开发的纳米温度计有效地解决了纳米级温度调节在MW热疗中的挑战.
- 这项技术可以精确监测细胞温度,为改进的基于MW的治疗策略铺平了道路.
- 纳米温度计的独特特性允许在治疗过程中在细胞层面实时绘制温度图.
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