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功能性抗炎性半孔氧化纳米平台用于协同和向的腹腔大动脉动脉瘤治疗

Zhaoyu Wu¹, Xiaoyu Wu¹, Xiangtian Meng²

¹Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Journal of colloid and interface science

|December 25, 2024

概括

新的纳米颗粒载有介素-1受体对抗剂 (IL-1Ra@MMSN) 有效向腹腔大动脉瘤 (AAA) 中的慢性炎症. 这种新型的抗炎方法对早期AAA干预和治疗有希望.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
心血管研究研究心血管研究

背景情况:

腹腔大动脉瘤 (AAA) 是一种具有高死亡率的炎症性疾病,缺乏有效的早期治疗方法.
目前针对AAA风险因素的治疗方法不足,这凸显了对新策略的需求.
针对AAA病变的抗炎方法提供了一个有前途的治疗途径.

研究的目的:

设计和合成载有介质素-1受体抗剂的胺合的半孔二氧化纳米粒子 (IL-1Ra@MMSN).
评估IL-1Ra@MMSN在腹腔大动脉动脉瘤 (AAA) 模型中治疗巨细胞介导慢性大动脉炎症的疗效.
探索IL-1Ra@MMSN作为AAA早期干预的潜在纳米平台.

主要方法:

合成和描述IL-1Ra@MMSN,评估负载效率,稳定性和pH响应释放.
通过TGF-β信号传递对IL-1Ra@MMSN对巨细胞氧化应激和M2极化的影响的体外评估.
在活体中评估IL-1Ra@MMSN的向性,生物相容性和治疗疗效在动脉素II诱导的小鼠AAA模型中.

主要成果:

IL-1Ra@MMSN表现出高药载荷,稳定性和受控释放.
在体外研究表明IL-1Ra@MMSN保护巨细胞免受氧化应激,并促进M2极化.
在体内实验证实IL-1Ra@MMSN的病变向性,生物相容性,并显著减少AAA形成和进展.

结论:

在AAA中,IL-1Ra@MMSN有效向巨细胞介导的炎症.
这种纳米平台通过保护大动脉完整性和促进抗炎环境来证明治疗潜力.
通过免疫调节,IL-1Ra@MMSN代表了早期腹腔大动脉动脉瘤干预的有前途的纳米医学策略.

关键词:

腹腔大动脉动脉瘤腹腔大动脉动脉瘤抗炎症疗法是一种抗炎症疗法.介素1受体对抗剂介素1受体对抗剂是一种.半孔的二氧化纳米粒子.

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