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Updated: Jun 4, 2025

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发现了右开读框激酶2 (RIOK2) 分子降解剂的第一个例子

Haowen Ma1, Cong Liu2, Zihao Li2

  • 1College of Chemistry and Materials Science, Zhejiang Normal University, No. 688 Yingbin Road, Jinhua, Zhejiang Province, 321004, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education, College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510530, China.

European journal of medicinal chemistry
|December 25, 2024
PubMed
概括

研究人员开发了CQ627,这是第一个用于RIOK2 (Right Open Reading Frame Kinase 2) 的分子降解剂. 这种新型化合物有效降解RIOK2,显示出比抑制剂更强的抗癌活性,并在体内有希望的结果.

关键词:
它们是ATP酶.降解器降解器降解器基因酶激酶的使用方法分子粘合剂是一种分子粘合剂.在RIOK2上,你会看到RIOK2.

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