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Updated: Jun 4, 2025

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

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新型N-arylspermidine衍生物的合成和体外雷什曼杀伤性活性

María C Mollo1, Mariana L Cambiaso2, Leonardo L G Ferreira3

  • 1Universidad de Buenos Aires, CONICET, Cátedra de Química Orgánica II, Departamento de Ciencias Químicas, Facultad de Farmacia y Bioquímica, Junín 956, 1113 Buenos Aires, Argentina; Laboratory of Medicinal and Computational Chemistry, Physics Institute of São Carlos, University of São Paulo, Av. Joao Dagnone 1100, 13563-120 São Carlos, SP, Brazil.

Bioorganic chemistry
|December 25, 2024
PubMed
概括

新型N-arylspermidine衍生物在治疗莱什曼病方面表现有前途. 八种化合物对Leishmania infantum细胞内巨菌具有有效性,其中一些药物表现出与现有治疗方法相当的效力.

关键词:
莱什曼病是一种莱什曼病.被忽视的疾病被忽视的疾病有机合成 有机合成聚氨酸是一种多氨酸.

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