微生物对来自宿主的抗氧化剂进行代谢
Zhe Zhou1, Stavroula K Hatzios2
1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520, USA; Microbial Sciences Institute, Yale University, West Haven, CT, 06516, USA.
Current opinion in chemical biology
|December 25, 2024
概括
肠道微生物将宿主抗氧化剂转化为营养和能源. 了解这些微生物代谢途径,通过调节宿主-微生物氧化还原平衡,为改善人类健康提供了新的途径.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 人类健康 人类健康 人类健康
背景情况:
- 哺乳动物细胞很难代谢许多饮食中的抗氧化剂.
- 胃肠道微生物拥有能够代谢这些氧化还原活性分子的酶.
- 这种微生物代谢可以产生营养和电子受体,支持肠道细菌的生长.
研究的目的:
- 要突出最近关于宿主衍生抗氧化剂的微生物代谢的研究.
- 为在体内绘制这些代谢途径的跨学科方法提供概述.
- 探索微生物抗氧化剂代谢对物种间相互作用的调节.
主要方法:
- 评论最近的科学文献.
- 介绍跨学科方法的描述.
- 在体内代谢途径映射.
主要成果:
- 抗氧化剂的微生物代谢影响肠道内的物种间相互作用.
- 肠道微生物中的酶将宿主抗氧化剂转化为细菌可用的化合物.
- 绘制这些路径对于理解宿主-微生物相互作用至关重要.
结论:
- 微生物驱动的对氧化还原活性小分子的生物转化为改善健康提供了机会.
- 调节宿主-微生物界面上的氧化还原反应可以改善人类健康.
- 对这些代谢途径的进一步研究是有必要的.
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