透明度,可信度和实用性在先兆子随机对照试验在过去的三十年
Hannah T Y Wang1, Yichi Zhang2, Rivani Porwal3
1Peninsula Health, Frankston, Victoria, Australia.
Pregnancy hypertension
|December 25, 2024
概括
自2010年以来,对子宫前的随机对照试验 (RCT) 的透明度和可信度有所提高. 需要进一步的改进,以最大限度地提高研究价值.
科学领域:
- 产科和妇科 产科和妇科
- 临床试验方法论 临床试验方法论
- 基于证据的医学 基于证据的医学
背景情况:
- 随机对照试验 (RCT) 调查子宫前的数量在最近几十年里稳步增加.
- 评估这些试验的质量和报告标准对于可靠的临床决策至关重要.
研究的目的:
- 评价1987年至2021年间发表的孕前试验试验的可信度,偏差风险,p值报告,透明度和有用性.
- 随着时间的推移,识别研究质量和报告的趋势.
主要方法:
- 在PubMed进行了系统的搜索,从1987年到2021年,在标题中搜索有"先兆子"或"妊娠高血压障碍"的RCT.
- 制定了一个检查清单,以评估透明度,可信度和有用性,并记录p值报告,试验注册,出版期刊和结果.
主要成果:
- 分析了202个RCT,显示作者数量增加,试验注册数量在2010年后增加了近7倍.
- 报告非显著的p值和效果大小增加,透明度和有用性得分也增加.
- 然而,充分的注册情况很差 (21%),报告,绩效和检测偏差的风险很普遍 (82%,65%,70%).
结论:
- 自2010年以来,强制性试验注册与非显著的p值和效果大小的报告的改进,以及提高透明度和可信度相吻合.
- 尽管有所改进,但预孕RCT需要更大的透明度,可信度和实用性,以提高其研究价值.
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