涂有酸盐的Olea europaea多纳米脂质体:制备,稳定性,释放和生物活性
Wenjun Li1, Lemonia Antoniadi2, Hao Zhou1
1Institute of Chemical Industry of Forest Products, CAF, National Engineering Laboratory for Biomass Chemical Utilization, Key and Open Laboratory on Forest Chemical Engineering, SFA, Key Laboratory of Biomass Energy and Material, Nanjing 210042, Jiangsu Province, China.
Food chemistry
|December 25, 2024
概括
超灵活的纳米脂质体 (UNL) 有效地封装了橄多,增强了它们的稳定性和通过皮肤传递. 这种新的方法改善了抗氧化剂和细胞毒性,为人类健康应用提供了潜力.
科学领域:
- 纳米技术纳米技术
- 药品制造 药品制造 药品制造
- 生物化学 生物化学
背景情况:
- 橄油多,如 (OLEO), (OLEA), (OLEU) 和 (HT) 具有显著的生物活性,但稳定性和生物利用性不佳.
- 开发有效的输送系统对于利用这些天然化合物的治疗潜力至关重要.
研究的目的:
- 制造超灵活的纳米脂质体 (UNL),以改善OLEO,OLEA,OLEU和HT的封装,稳定性和通过皮肤传递.
- 评估多烯载荷UNL的物理化学特性,体外释放动力学和生物活性.
主要方法:
- 使用薄膜水化技术制造UNL,然后使用DLS,FTIR,XRD,TGA和DSC进行表征.
- 阴性染色TEM用于囊泡形态评估.
- 在体外通过皮肤释放的研究和运动模型 (Peppas-Sahlin,Korsmeyer-Peppas,Higuchi).
- 评估抗氧化剂和细胞毒性特性.
主要成果:
- UNL成功封装了OLEO,OLEA,OLEU和HT,表现出分散的层状囊泡结构.
- 在体外通过皮肤进行的研究显示,封装多的累积释放显著增强 (OLEO为3.13倍).
- 释放动力学遵循Peppas-Sahlin模型,表明Fickian扩散.
- 与自由化合物相比,UNL配方表现出更好的抗氧化剂和细胞毒性.
结论:
- 超灵活的纳米脂质体为稳定和增强橄多的通过皮肤传递提供了一个有前途的平台.
- 封装UNL聚醇的提高生物活性凸显了它们在各种人类健康应用中的潜力.
- 这项研究提供了一种新的策略,用于利用Olea europaea衍生化合物在药品和营养药品配方中.
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