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Updated: Jun 15, 2026

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工程GU基对的一般策略,以促进RNA结晶

Yangyi Ren1, Xiaowei Lin1,2,3, Wenjian Liao1,2

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

Nucleic acids research
|December 25, 2024
PubMed
概括

研究人员开发了一种简单的方法,使用GU基对来提高RNA晶体分辨率. 该技术增强了X射线结晶学数据,使得高分辨率的RNA结构确定.

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相关概念视频

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...