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扩散型大B细胞淋巴瘤具有多叶核形态携带t (14;18) (q32;q21) 和t (3;22) (q27;q11):一个病例报告

Masahiro Manabe¹, Naoyuki Inano², Yuuji Hagiwara²

¹Department of Hematology, Osaka General Hospital of West Japan Railway Company, Japan.

Internal medicine (Tokyo, Japan)

|December 25, 2024

概括

本案例研究突出了一个罕见的分布式大B细胞淋巴瘤 (DLBCL) 呈现,具有多叶核. 尽管有典型的预后指标,但特定的染色体转位导致了积极的临床过程.

科学领域:

血液学血液学血液学
在瘤学瘤学.
细胞病理学细胞病理学

背景情况:

扩散型大B细胞淋巴瘤 (DLBCL) 是一种侵略性的非霍奇金淋巴瘤.
DLBCL的形态变异,如多叶核,可以发生,但不太常见.
在DLBCL中核形态的预后意义需要进一步调查.

研究的目的:

报告一例DLBCL病例,该病例呈现出在多溢液中非典型的多核.
为了研究这种罕见的DLBCL呈现的细胞遗传和临床特征.
讨论特定染色体转位对DLBCL预后的潜在影响.

主要方法:

对非典型细胞的肺溢液的细胞病理学分析.
细胞块分析用于确定DLBCL诊断.
淋巴瘤细胞的染色体分析 (kariotyping) 以确定遗传异常.

主要成果:

通过细胞块分析证实DLBCL的诊断.
在淋巴瘤细胞中识别染色体转位 t(14;18) 和 t(3;22).
患者表现出化学疗法的折射性,导致在一年内死亡.

结论:

虽然在其他淋巴瘤中是典型的,但在DLBCL中可以观察到多叶细胞核.
特定的染色体转位,t(14;18) 和t(3;22),可能与DLBCL的侵袭性临床过程有关,超过潜在的有利形态特征.

关键词:

扩散大的B细胞淋巴瘤.细胞块的细胞块是什么?形态学形态学形态学在t (14;18) (q32;q21),t (3;22) (q27;q11) 的时间段内.

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