在日本COVID-19的前三波中长期COVID:一个多中心队列研究
Hatsuyo Takaoka1, Ichiro Kawada2,3, Gaku Hiruma4
1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
BMJ open respiratory research
|December 25, 2024
概括
在日本首次COVID-19浪潮期间住院的患者的长期COVID发病率更高,尤其是呼吸障碍. 这凸显了对幸存者持续症状的持续监测和管理的需要.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 已经造成全球大流行.
- 长期冠状病毒病 (长期COVID) 在COVID-19感染后呈现持续症状.
- 对于公共卫生战略来说,了解跨大流行波的长期COVID变异至关重要.
研究的目的:
- 为了调查在日本的前三次COVID-19大流行浪潮期间住院的患者中长期COVID患病率的差异.
- 为了确定与不同波长COVID相关的特定症状和风险因素.
主要方法:
- 一项多中心前性队列研究,涉及26个日本医疗机构的1066名住院COVID-19患者.
- 数据收集发生在2020年2月至2021年2月期间.
- 长期COVID症状,包括呼吸障碍,在诊断后的3,6个月和12个月被评估.
主要成果:
- 在三次大流行浪潮中观察到基线特征和临床因素的显著变化.
- 长期COVID,特别是呼吸障碍,在第一波期间住院的患者中最为普遍.
- 多变量分析证实了第一波疫情与长期COVID和呼吸障碍风险增加之间的显著关联,即使对共变量进行调整后也是如此.
结论:
- 在最初的COVID-19浪潮期间住院与患长期COVID的风险更高,特别是呼吸障碍.
- 这些发现强调了持续监测和针对COVID-19幸存者的量身定制管理策略的重要性,特别是那些在流行病早期被感染的人.
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