在质量设计驱动研究中利用绿色色染色学,同时分析基本单片抗糖尿病药物组合
Adel Ehab Ibrahim1,2, Samy G Alamir1,3, Khaled Maged1,4
1Natural and Medical Sciences Research Center, University of Nizwa, Nizwa City, Oman.
Journal of separation science
|December 25, 2024
概括
这项研究引入了cyrene作为一种安全的绿色溶剂替代品,用于分析抗糖尿病药物的状液体染色学 (MLC). 新的无有机溶剂方法确保了高效的分离和质量控制,减少了对环境的影响.
科学领域:
- 分析化学 分析化学
- 绿色化学 绿色化学
- 染色体学 染色体学 是一种染色学.
背景情况:
- 状液体色谱 (MLC) 为质量控制提供了效率和环保性.
- 传统方法通常依赖于有机溶剂,造成环境问题.
- 开发更绿色的替代品对于可持续的分析实践至关重要.
研究的目的:
- 研究cyren作为一种新的,安全的有机溶剂,用于逆相MLC.
- 为抗糖尿病药物开发和验证一种无有机溶剂的MLC方法.
- 评估开发的分析方法的绿色性.
主要方法:
- 通过设计质量 (QbD) 方法用于选绿色添加剂.
- 使用了无有机溶剂的移动相 (Brij-35,二甲硫酸盐,酸).
- 使用RP-C18核心柱进行了六种抗糖尿病药物的分离 (甲型胺,empagliflozin, ertugliflozin,linagliptin,sitagliptin,gliclazide).
主要成果:
- 系统的适用性证实了MLC在不牺牲分离效率的情况下消除有机溶剂的能力.
- 该方法证明了研究药物的各种度范围的成功验证.
- 在单个和多组分药片中实现了精确的分析剂的确定.
- 使用MoGAPI和AGREE指标进行的绿色评估支持了该方法的环境效益.
结论:
- 锡林是一种可行的,安全的替代性有机溶剂,用于MLC.
- 开发的无有机溶剂MLC方法是高效的,适合用于抗糖尿病药物的常规质量控制.
- 这种方法显著有助于绿色分析化学实践.
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