乳酸菌种群的有效性. 在Helicobacter pylori消灭中补充:随机对照试验的系统分析与试验序列分析
Vivek Mishra1, Debabrata Dash1, Aditya K Panda1,2
1Department of Biotechnology, Berhampur University, Berhampur, Odisha, India.
益生菌,如乳杆菌种类. 当与标准治疗相结合时,可显著提高Helicobacter pylori根除率. 这些益生菌还有助于减少常见的胃肠道副作用,如恶心,吐和腹.
科学领域:
- 胃肠道学和微生物学
- 临床研究和治疗学
背景情况:
- 杆菌感染是一个重要的全球健康问题,与各种胃肠道疾病有关.
- 益生菌,特别是乳酸菌种,因其在治疗H.pylori感染方面的潜在益处而得到认可.
研究的目的:
- 为了评估Lactobacillus spp.的疗效. 补充剂可以提高H. pylori根除率.
- 评估Lactobacillus spp.的影响. 减少与H. pylori标准治疗相关的胃肠道副作用.
主要方法:
- 进行了随机对照试验 (RCT) 的元分析.
- 研究在主要的数据库中进行了系统的搜索:PubMed,Scopus,Google Scholar和Cochrane图书馆.
- 使用综合元分析 (CMA) 软件4.0,试验序列分析 (TSA) 软件和GRADEpro GDT进行统计分析,以评估证据的确定性.
主要成果:
- 乳杆菌菌种类. 乳杆菌种类. 补充剂在每项方案分析和特定子组 (成人和儿童) 中显著增加了H. pylori根除率.
- 补充使用 Lactobacillus spp. 的补充. 与四重疗法相比,三重疗法显示出显著的益处.
- 乳杆菌菌种类. 乳杆菌种类. 显著降低了恶心/吐,腹和腹痛的发生率,尽管对胀气的影响并不显著.
- 具体的补充时间 (14天和28-30天) 显示了根除率的最大改善.
结论:
- 乳杆菌菌种类. 乳杆菌种类. 补充剂是一种有效的辅助治疗,用于提高H. pylori根除率,当与标准治疗一起使用时.
- 乳酸菌种类的使用. 除了标准的H. pylori治疗外,可以显著减轻常见的胃肠道副作用.
- 这些发现得到了TSA和GRADEpro评估的支持,表明这些有益影响的证据具有很高的确定性.
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