皮肤先天性淋巴细胞种群驱动IL-17A介导的免疫力在南尼西亚吉普赛皮肤植物病
Ignacio Beccacece1, Verónica Liliana Burstein1, Mariel Abigail Almeida1
1Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), National Scientific and Technical Research Council (CONICET), Córdoba, Argentina.
The Journal of investigative dermatology
|December 26, 2024
概括
皮肤对真菌感染的免疫包括产生IL-17A的关键T细胞. 天生的淋巴细胞也对抗真菌防御有所贡献,显示出对皮肤植物病的协调免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 微生物学 微生物学
背景情况:
- 真菌性皮肤感染 (皮质植物病) 构成了全球重大健康挑战.
- 了解皮肤对皮肤细胞的免疫力至关重要,但有限.
- 之前的研究已经确定了IL-17RA信号传递在对抗Microsporum canis感染中的作用.
研究的目的:
- 在Nannizzia gypsea dermatophytosis期间调查IL-17A的细胞来源.
- 阐明T细胞和先天性淋巴细胞在皮肤抗真菌免疫中的作用.
- 为了确定淋巴结原始化对局部皮肤防御的贡献.
主要方法:
- 使用了一种鼠标模型,对皮性Nannizzia gypsea感染.
- 采用流细胞测量来识别IL-17A产生T细胞子集 (γδTCRint,CD8/CD4双阴性βTCR+).
- 使用fingolimod来限制淋巴细胞贩运,并使用Rag1-/-和Rag2-/-Il2rg-/-小鼠来评估免疫细胞的贡献.
主要成果:
- 皮肤的γδT和CD8/CD4双阴性βTCR+ T细胞被确定为主要的IL-17A生产者.
- 这些IL-17A+ T细胞表现出激活/记忆表型,包括增殖组织居民细胞.
- 当地抗真菌防御是有效的,即使淋巴细胞的贩运受到限制,独立于淋巴结的初始化.
- 拉格1-/-小鼠通过从先天性淋巴细胞 (ILCs) 来增强IL-17A控制感染.
- 缺少T,B和ILC的Rag2-/-Il2rg-/-小鼠表现出高灵敏度,证实了T细胞缺乏环境中的ILC足够性.
结论:
- 皮肤的 γδT 细胞和特定的 αβT 细胞子集是Nannizzia gypsea 感染期间 IL-17A 的关键生产者.
- 天生的淋巴细胞在抗真菌免疫中起着至关重要的作用,特别是在没有T细胞的情况下.
- 皮肤对皮肤植物病的皮肤免疫包括皮肤内的适应性和先天性免疫细胞之间的协调反应.
相关概念视频
01:24T Cell Types and Functions
947
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
947
01:27Cytotoxic T Cells-mediated Immune Response
844
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
844