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在慢性咳治疗中的治疗和机械学的进步
Anju T Peters1, Ken W Altman2, Peter Dicpinigaitis3
1Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
概括
慢性咳 (CC) 影响全球10%的成年人,严重影响生活质量. 耐火性CC (RCC) 可能涉及神经元失调,新的治疗方法显示出希望.
科学领域:
- 肺部病理学 肺部病理学
- 神经学 神经学
背景情况:
- 慢性咳 (CC) 是一种普遍的疾病,影响全球大约10%的成年人.
- CC显著损害了患者的身体,社会和心理福祉.
- 常见的原因包括上呼吸道咳综合征,逆流和喘,但持续咳被称为耐火性CC (RCC).
研究的目的:
- 审查耐火性慢性咳 (RCC) 的病理生理学和当前/新兴治疗方法.
主要方法:
- 关于慢性咳,耐火性慢性咳,咳过敏综合征和治疗选择的文献综述.
- 讨论目前基于指导方针的CC的评估和治疗方法.
- 探索RCC的新兴疗法.
主要成果:
- 耐火性CC (RCC) 与咳过敏综合征有关,涉及神经元失调.
- 目前对RCC的治疗包括非标记的神经调节剂和语言治疗.
- 作为P2×3受体对手的Gefapixant在某些地区已被批准用于RCC.
结论:
- 耐火性慢性咳 (RCC) 由于底层神经元机制,提出了独特的挑战.
- 虽然已确立的治疗方法存在,但像 gefapixant 这样的新疗法为管理RCC提供了新的途径.
- 对新兴治疗方法的进一步研究对于改善耐火性慢性咳患者的治疗结果至关重要.
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